Which of the following mechanisms characterizes the usual action of most oncogenes?

Question

Quizplus · Accepted Answer

Gain-of-function mutations in oncogenes lead to constitutive activation of the encoded protein, promoting cell growth and proliferation.  An oncogene is a gene that has the potential to cause cancer and results from alteration in a proto-oncogene, either mutation or altered expression. Cancer normally results due to a dominant gainof-function mutation or gain-of-function changes in the expression of the proto-oncogene.

Which of the Following Mechanisms Characterizes the Usual Action of Most