An alternative to the dopamine hypothesis of schizophrenia is the proposal that schizophrenia may be due to a deficiency of activity of ____ synapses.
A) serotonin
B) glutamate
C) substance P
D) acetylcholine

Question

Quizplus · Accepted Answer

The proposal that schizophrenia may be due to a deficiency of activity of glutamate synapses is known as the glutamate hypothesis. This hypothesis suggests that decreased glutamate activity leads to decreased activation of NMDA receptors, which in turn leads to a reduction in neural plasticity and cognitive deficits observed in schizophrenia.

An Alternative to the Dopamine Hypothesis of Schizophrenia Is the Proposal