A hemophilic A patient has a severe bleed and is being treated with Factor VIII concentrate. When testing his post infusion, the factor VIII level does not increase. The problem could be:
A) Lupus anticoagulant
B) Improper drawing of the specimen
C) Factor VIII inhibitor
D) Factor IX inhibitor

Question

Quizplus · Accepted Answer

A lack of increase in Factor VIII level after infusion suggests the presence of a Factor VIII inhibitor, which is an antibody that neutralizes the therapeutic effects of Factor VIII concentrate. Lupus anticoagulant and improper drawing of the specimen would not affect the increase in Factor VIII level post-infusion. Factor IX inhibitor would not affect the response to Factor VIII concentrate.

A Hemophilic a Patient Has a Severe Bleed and Is