A 58-year-old male visits his physician for extreme fatigue.After conducting a standard investigation, the physician strongly suspects that his patient is suffering from CML.Which one of the following lab results would confirm this picture?

Question

Quizplus · Accepted Answer

Positive molecular analysis for BCR-ABL is a confirmatory test for chronic myeloid leukemia (CML). It detects the presence of the Philadelphia chromosome, which is formed due to the reciprocal translocation of 9 and 22 chromosomes leading to the formation of the BCR-ABL fusion gene. The BCR-ABL protein has been identified as the causative agent in CML. The other options listed may be seen in CML, but they are not specific for its diagnosis.

A 58-Year-Old Male Visits His Physician for Extreme Fatigue