Ingram examined hemoglobin structural variation by breaking down the hemoglobin protein into many fragments by chemical treatment and subjecting the fragments to electrophoresis to separate them in a gel; and then in a second dimension, perpendicular to the first, he separated them by chromatography. This two-step approach is commonly referred to as __________.

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The two-step approach described by Ingram is commonly referred to as peptide fingerprint analysis, as it involves breaking down the protein into fragments and analyzing the resulting pattern of fragments to identify structural variations. Hybridization, electrophoretic mobility, densitometry, and restriction fragment analysis are not relevant to this technique.

Ingram Examined Hemoglobin Structural Variation by Breaking Down the Hemoglobin