Which of these factors led to the occurrence of plagues (epidemics of disease)in human society? (Select all that apply)

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Plagues and epidemics of disease occurred due to various factors, including close contact with domesticated animals (B), travel to new parts of the world and returning home with new diseases (C), and the establishment of towns where people lived in close proximity to each other (D). While overall populations as large as those seen today (A) can contribute to the spread of disease, it is not the primary factor. Bloodletting (E) was a medical practice that was sometimes used to treat diseases, but it did not contribute to the occurrence of plagues.

Which of These Factors Led to the Occurrence of Plagues