The Therapist Taking Care of an Infant on INO Observes

The therapist taking care of an infant on iNO observes that the NO₂ levels have been increasing.In order to correct the situation he increases the inspiratory flow of the ventilator.What will be some of the limitations associated with this change?
I.It reduces time of contact between NO and O₂.
II.It affects the mean airway pressure because it changes the inspiratory time.
III.It may increase the delivered tidal volume.
IV.It reduces the mean airway pressure and increases the inspiratory time.

A) I only
B) II and IV only
C) I,II,and III only
D) II,III,and IV only