The pharmaceutical drug RU-486 is sometimes used for medical abortions. RU-486 blocks progesterone production. It cannot cross from the mother's blood into the placenta. The drug loses most of its abortive properties after the 1ˢᵗ trimester. This is likely because after the 1ˢᵗ trimester, the ________ begins producing a sufficient supply of progesterone and estrogen.
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