When diagnosed with hemolytic disease of the fetus and newborn (HDFN), why does the newborn develop hyperbilirubinemia after birth but not in utero?
A)Excretion of unconjugated bilirubin through the placenta into the mother's circulation is no longer possible.
B)Hemoglobin does not breakdown into bilirubin in the intrauterine environment.
C)The liver of the fetus is too immature to conjugate bilirubin from a lipid-soluble to water-soluble form.
D)The destruction of erythrocytes producing bilirubin is greater after birth.

Question

Quizplus · Accepted Answer

Hyperbilirubinemia occurs in the neonate after birth because excretion of lipid-soluble unconjugated bilirubin through the placenta is no longer possible. HDFN is not related to hemoglobin failing to breakdown, an immature liver, or destruction of erythrocytes being greater after birth.

When Diagnosed with Hemolytic Disease of the Fetus and Newborn