A professor has taught a student about skeletal alterations seen in chronic kidney disease. Which statement by the student indicates the professor needs to give more information?
A)Parathyroid hormone is no longer effective in maintaining serum phosphate levels.
B)The parathyroid gland is no longer able to secrete sufficient parathyroid hormone.
C)The synthesis of 1,25-vitamin D3, which reduces intestinal absorption of calcium, is impaired.
D)The effectiveness of calcium and phosphate resorption from bone is impaired.

Question

Quizplus · Accepted Answer

Bone and skeletal changes develop with alterations in calcium and phosphate metabolism. These changes begin when the GFR decreases to 25% or less. The combined effect of hyperparathyroidism and vitamin D deficiency can result in renal osteodystrophies (e.g., osteomalacia, osteitis fibrosa with increased risk for fractures). Other consequences of secondary hyperparathyroidism include soft tissue and vascular calcification, cardiovascular disease, and, less commonly, calcific uremic arteriolopathy. The other statements are true.

A Professor Has Taught a Student About Skeletal Alterations Seen