Which of the following is the best-known substrate of the interferon induced PKR?

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The interferon-induced protein kinase R (PKR) is activated by interferons and its best-known substrate is the translation factor eIF2α. When PKR is activated, it phosphorylates eIF2α, leading to inhibition of protein synthesis and increased susceptibility of infected cells to apoptosis. This is an important antiviral response that allows the infected cell to limit viral replication and spread.

Which of the Following Is the Best-Known Substrate of the Interferon