Which of the Following Events Causes a Naïve T Lymphocyte

Which of the following events causes a naïve T lymphocyte to become activated and differentiate into an effector T cell?

A) The T cell receptor recognizes its epitope on a peptide presented on MHC-I.
B) The T cell receptor recognizes its epitope on a peptide presented on MHC-II
C) A T helper cell releases IL-12 and causes it to differentiate.
D) A macrophage releases IL-4 and causes it to differentiate.
E) The T cell interacts with a B cell that recognizes the same epitope.