Which of the following is a description consistent with chronic myelogenous leukemia (CML)?
A) There are defects in the ras oncogene,p53 tumor suppressor gene,and INK4A,the gene encoding a cell-cycle regulatory protein.
B) The bone marrow and peripheral blood are characterized by leukocytosis and a predominance of blast cells.As the immature blasts increase,they replace normal myelocytic cells,megakaryocytes,and erythrocytes.
C) There is failure of B cells to mature into plasma cells that synthesize immunoglobulins.
D) The translocation of genetic material from genes 9 and 22 create an abnormal,fused gene identified as BCR-ABL.

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Chronic myelogenous leukemia (CML) is characterized by the translocation of genetic material from genes 9 and 22, creating an abnormal fused gene identified as BCR-ABL. This leads to uncontrolled proliferation of myeloid cells in the bone marrow and peripheral blood. A) describes pancreatic cancer, B) describes acute myeloid leukemia, and C) describes common variable immunodeficiency.

Which of the Following Is a Description Consistent with Chronic