Which of the following is a description consistent with chronic lymphocytic leukemia (CLL)?
A) There are defects in the ras oncogene,p53 tumor suppressor gene,and INK4A,the gene encoding a cell-cycle regulatory protein.
B) The bone marrow and peripheral blood are characterized by leukocytosis and a predominance of blast cells.As the immature blasts increase,they replace normal myelocytic cells,megakaryocytes,and erythrocytes.
C) There is failure of B cells to mature into plasma cells that synthesize immunoglobulins.
D) The translocation of genetic material from genes 9 and 22 create an abnormal,fused gene identified as BCR-ABL.

Question

Quizplus · Accepted Answer

Chronic lymphocytic leukemia (CLL) is a slowly progressing cancer of the blood and bone marrow that affects lymphocytes, specifically B cells. In CLL, the B cells do not fully mature and are unable to produce functional antibodies, leading to weakened immunity. It is not associated with defects in the ras oncogene, p53 tumor suppressor gene, INK4A gene, leukocytosis, blast cells, or the BCR-ABL fusion gene, which are more commonly associated with other types of leukemia.

Which of the Following Is a Description Consistent with Chronic