The evaluation of HER2/neu has what clinical function?

Question

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Oncogenes have been associated with various tumor types (e.g. ,HER2/neu with breast,kidney,and ovarian cancer).Overexpression of the c-erbB-2 oncogene (HER2/neu)is noted in up to 34% of patients with invasive ductal breast carcinoma and predicts poor survival.
A relatively new approach has been the use of the oncogene HER2/neu as a prognostic indicator and a marker related to the choice of therapy.This has been particularly useful since the introduction of trastuzumab (Herceptin)as a chemotherapeutic agent that targets the HER-2/neu receptor.Patients with breast cancer who express HER-2/neu in their cancers have a poor prognosis,with shorter disease-free and overall survival than patients who do not express HER2/neu.The evaluation of HER2/neu has two clinical functions: (1)a predictive marker for response to trastuzamab therapy and (2)a prognostic marker.

The Evaluation of HER2/neu Has What Clinical Function