A scientist wishes to develop an antimicrobial agent that specifically targets replication elongation in Escherichia coli without interfering with proteins that catalyze other replication processes.Which of the following experimental designs is most appropriate for the scientist to explore?

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The question specifically asks for an antimicrobial agent that targets replication elongation in E. coli without interfering with other replication processes. The most appropriate way to achieve this is by targeting a specific component involved in this process, such as DNA polymerase III core enzyme. Developing a molecule that interferes with its DNA-binding ability would inhibit replication elongation without affecting other replication processes. Modifying an existing antibiotic or designing a drug that modifies the structural configuration of DNA may have unintended effects on other replication processes, while creating a novel protein that acts as a competitive inhibitor of DNA ligase binding site does not specifically target replication elongation.

A Scientist Wishes to Develop an Antimicrobial Agent That Specifically