Which of the Following Is True of Neurotransmitter Function

Which of the following is true of neurotransmitter function?

A) Neurotransmitters diffuse widely across the brain to exert changes in metabolism.
B) Neurotransmitters directly alter ion channels using a second-messenger chemical.
C) Neurotransmitters are released into the synapse from the cistaerna.
D) Neurotransmitters open ion channels in the postsynaptic membrane.
E) Neurotransmitters alter ion channel activity for minutes.