With the onset of the California gold rush in 1849, many Plains Indians, led by the Cheyenne:

Question

Quizplus · Accepted Answer

The Plains Indians, including the Cheyenne, supplied buffalo meat and skins to the white pioneers during the California gold rush. They saw this as an opportunity to trade with the newcomers for goods and guns. However, this led to the decline of the buffalo population and conflicts with white settlers over land and resources.

With the Onset of the California Gold Rush in 1849