Tropheryma whipplei is the causative agent for Whipple's disease. It could not be cultured until recently when the genomic data showed:

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The genomic data showed that Tropheryma whipplei is auxotrophic for some amino acids, meaning it is unable to synthesize certain amino acids on its own and requires them from its environment. This is why it could not be cultured until recently, as previous culture techniques did not provide the necessary amino acids.

Tropheryma Whipplei Is the Causative Agent for Whipple's Disease