The Major Challenge with Treating Flesh-Eating Disease Caused by Streptococcus

The major challenge with treating flesh-eating disease caused by Streptococcus pyogenes is that:

A) the bacterium is a multidrug resistant pathogen
B) no antibiotic is useful because it's a mixed infection
C) toxin encoding phage also encode antibiotic degrading enzymes
D) the causative agent is a MRSA
E) rapid necrosis of infected tissue limits access