Due to the lack of an enzyme to break down lipids,excess accumulation of lipids in the brain leads to a human disease called Tay Sachs syndrome.The organelle most likely to lack the proper enzyme needed for lipid breakdown is

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Lysosomes are responsible for the breakdown of macromolecules, including lipids. Therefore, if there is a lack of an enzyme needed to break down lipids, it is most likely that the lysosomes are unable to perform their function.

Due to the Lack of an Enzyme to Break Down