According to the First Law of Thermodynamics,the Energy of the Universe

According to the first law of thermodynamics,the energy of the universe is constant.Does this mean that ΔE is always equal to zero?

A) No,ΔE does not always equal zero,but this is due only to factors such as friction and heat.
B) No,ΔE never equals zero because energy is always flowing between the system and the surroundings.
C) No,ΔE does not always equal zero because it refers to the system's internal energy,which is affected by heat and work.
D) Yes,ΔE = 0 at all times,which is why q = -w.
E) No,ΔE never equals zero because work is always being done on the system or by the system.