Which of the following effects is an acidic drug such as aspirin likely to produce in the body?

Question

Quizplus · Accepted Answer

Many drugs are weak acids (aspirin, barbiturates, and penicillin) or weak bases (opioid analgesics and antihistamines), which also are secreted into the tubular fluid through the proximal convoluted tubules. Metabolic waste products (weak acids, weak bases) compete for the same transport sites that excrete these drugs. This competition can result in altered drug excretion-for example, accumulation in the blood. Any condition that impairs the renal production of hydrogen and bicarbonate ions alters the acid-base balance of the body. For example, insufficient bicarbonate production because of carbonic anhydrase inhibition leads to metabolic acidosis.

Which of the Following Effects Is an Acidic Drug Such