Why Do Protease Inhibitors Work So Well When Used in Conjunction

Why do protease inhibitors work so well when used in conjunction with antiviral nucleosides?

A) This is an example of using the synergistic effect to our advantage.
B) The protease inhibitors facilitate the transport of antiviral nucleosides to the virus.
C) Protease inhibitors have the affect of "awakening" the virus thereby making the virus more susceptible to attack by the antiviral nucleoside.
D) all of the above