How does CoASH used in biological systems to activate carboxylic acids?

Question

Quizplus · Accepted Answer

CoASH (coenzyme A) is involved in the activation of carboxylic acids by converting them into thioesters. This is an important step in many biological processes, including fatty acid metabolism and the citric acid cycle. Thioesters are more reactive than regular esters and can undergo various enzymatic reactions, such as transesterification, acylation, and nucleophilic substitution. This reaction is also known as the acyl-CoA synthetase reaction, which requires ATP hydrolysis to drive the formation of the thioester bond.

How Does CoASH Used in Biological Systems to Activate Carboxylic