What is the initial event in the pathogenesis of idiopathic pulmonary artery hypertension (IPAH)?

Question

Quizplus · Accepted Answer

The initial event in IPAH pathogenesis is an insult to the pulmonary endothelium, leading to endothelial dysfunction, vasoconstriction, and ultimately vascular remodeling. This insult can be triggered by genetic mutations or environmental factors such as infection or drug exposure.

Answer: B
 While elevated serotonin levels are associated with the development of pulmonary hypertension, it is not the initial event in IPAH pathogenesis. Serotonin contributes to vasoconstriction and proliferation of smooth muscle cells, leading to vascular remodeling.

Answer: C
 Monoclonal proliferation of endothelial cells is not an initial event in IPAH pathogenesis. Rather, it is thought to contribute to the later stages of disease, as a result of genetic mutations or other factors.

Answer: D
 Vascular remodeling is a consequence of the initial insult to the pulmonary endothelium in IPAH pathogenesis, rather than the initiating event itself.

What Is the Initial Event in the Pathogenesis of Idiopathic