In conventional peptide synthesis,the nitrogen of a given amino acid must be deactivated or blocked while the carboxyl group is activated.Which of the following reagents is used to protect the amino group of an amino acid?

Question

Quizplus · Accepted Answer

Di-tert-butyl dicarbonate (Boc) is commonly used to protect the amino group of an amino acid in conventional peptide synthesis. It is able to selectively react with the amino group, forming a stable Boc-amino acid derivative that can be deprotected later in the synthesis. Other reagents listed may be used in other steps of peptide synthesis, but not for protecting the amino group.

In Conventional Peptide Synthesis,the Nitrogen of a Given Amino Acid