Which of the following explains the kinetic stability of ATP?
A)The hydrolysis of ATP occurs rapidly in the absence of a catalyst because the phosphate bonds are thermodynamically labile.
B)ATP is positively charged at physiological pH.
C)Water,the major component of cytoplasm,is a strong and very reactive nucleophile.
D)ATP is negatively charged at physiological pH and thus repels the approach of nucleophiles.
E)none of the above

Question

Quizplus · Accepted Answer

ATP is negatively charged at physiological pH due to the presence of multiple phosphate groups. This negative charge repels the approach of nucleophiles, which reduces the likelihood of spontaneous hydrolysis and gives ATP its kinetic stability.

Which of the Following Explains the Kinetic Stability of ATP