How could a potential alloimmunizaton due to Anti-K be prevented?

Question

Quizplus · Accepted Answer

The best way to prevent alloimmunization due to Anti-K is to match the donor and recipient red blood cell phenotype. This way, the recipient will receive red blood cells that do not have the K antigen and will not trigger an immune response.

Option B is not relevant to preventing alloimmunization due to Anti-K. Leukocyte filters are used to remove white blood cells, which can cause febrile non-hemolytic transfusion reactions and reduce the risk of transfusion-associated graft-versus-host disease.

Option C involves washing red blood cells to remove plasma proteins, which can also cause transfusion reactions. It does not specifically address the risk of alloimmunization due to Anti-K.

Option D is not relevant to preventing alloimmunization due to Anti-K either, as platelets do not express the K antigen. Apheresed platelets are typically used in patients who require frequent or large-volume platelet transfusions, or have a history of transfusion reactions to pooled platelets.

How Could a Potential Alloimmunizaton Due to Anti-K Be Prevented