In multiple myeloma, a plasma cell will sometimes contain clumps of aggregated immunoglobulin that stain red with Wright-Giemsa stain. These aggregates are referred to as:

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Russell bodies are eosinophilic inclusions in plasma cells that contain accumulated and retained immunoglobulins. They stain red with Wright-Giemsa stain and are commonly seen in multiple myeloma. The other options are associated with different conditions: Howell-Jolly bodies are nuclear remnants in red blood cells, Flame cells are associated with renal disease, Basophilic stippling is seen in lead poisoning, and Döhle bodies are associated with bacterial infections.

In Multiple Myeloma, a Plasma Cell Will Sometimes Contain Clumps