The blue sclera allele has 75 percent penetrance for producing blue sclera, 60 percent penetrance for fragile bones, and 40 percent penetrance for deafness.If these probabilities of penetrance are independent, _______ percent of individuals with the blue sclera allele will be unaffected.

Question

Quizplus · Accepted Answer

To find the percentage of individuals with the blue sclera allele who will be unaffected by any of the conditions (blue sclera, fragile bones, deafness), we need to calculate the probability that an individual will not express any of these traits. The penetrance values given are for the traits being expressed, so we first find the probabilities of these traits not being expressed (i.e., the individual is unaffected by that particular trait).- For blue sclera, the penetrance is 75%, so the probability of not having blue sclera is 25% (100% - 75%).- For fragile bones, the penetrance is 60%, so the probability of not having fragile bones is 40% (100% - 60%).- For deafness, the penetrance is 40%, so the probability of not being deaf is 60% (100% - 40%).Since these probabilities are independent, we multiply them to find the overall probability of an individual being unaffected by any of the conditions:25% * 40% * 60% = 0.25 * 0.4 * 0.6 = 0.06 or 6%Therefore, 6% of individuals with the blue sclera allele will be unaffected by blue sclera, fragile bones, and deafness.

The Blue Sclera Allele Has 75 Percent Penetrance for Producing