You grow some B cells in laboratory culture and find that they are expressing IgM, which reacts to sheep red blood cells.Later you test the growth medium and find almost no IgM, but a large amount of IgG.The IgG also reacts to sheep red blood cells.If you were to analyze the cells before and after the switch in antibody, you would see that the IgG being produced by the B cells have a different _______ when compared to the IgM.

Question

Quizplus · Accepted Answer

The switch from IgM to IgG production in B cells involves a change in the heavy chain constant region, not the variable region or other components. This process is known as class switching and affects the constant region of the antibody, altering its isotype (e.g., from IgM to IgG) while preserving its antigen specificity.

You Grow Some B Cells in Laboratory Culture and Find