The observation that a self-antigen present in multiple organs may be the target of autoimmunity in only one organ

Question

Quizplus · Accepted Answer

This observation underscores the importance of microenvironmental triggers, which can lead to the breakdown of immune tolerance towards a self-antigen in a specific tissue or organ, even if that antigen is present elsewhere in the body.

Answer: B and D are incorrect answers. The observation does not necessarily prove that single genetic loci are involved, nor does it require that risk-associated loci must be linked to cytokine genes. Autophagy is a cellular process of self-degradation and is not relevant to this observation.

The Observation That a Self-Antigen Present in Multiple Organs May