In humans, xeroderma pigmentosum (XP) is a disorder of the nucleotide excision repair mechanism. These individuals are unable to repair DNA damage caused by ultraviolet light. Which of the following are the most prominent types of DNA lesions in individuals suffering from xeroderma pigmentosum?
A) mismatch errors
B) telomere shortening
C) methylation of purines
D) thymine dimers

Question

Quizplus · Accepted Answer

Thymine dimers are the most prominent type of DNA lesions in individuals with xeroderma pigmentosum as they are a result of UV-induced damage.-Xeroderma pigmentosum results in the inability to repair this type of DNA damage, leading to a higher frequency of thymine dimers and increased risk for skin cancer.

In Humans, Xeroderma Pigmentosum (XP) Is a Disorder of the Nucleotide