A block in the stage of lymphocyte development described in questions will be caused by a mutation in which of the genes listed (A-F)?
-Pro-B cell to pre-B cell
A)RAG-2
B)Ikaros
C)l5 surrogate light chain
D)CD3e
E)TAP-1
F)Jak3

Question

Quizplus · Accepted Answer

Pro-B to pre-B transition requires expression of Ig F1F1F1S1F1F1F10 heavy chains.Functional F1F1F1S1F1F1F10 heavy chain genes are formed by RAG-1- and RAG-2-dependent VDJ recombination.

A Block in the Stage of Lymphocyte Development Described in Questions