One early study on DNA vaccines examined the CD8 T cell response to the plasmid-encoded antigenic protein following subcutaneous immunization of mice with the plasmid DNA. This study used bone marrow chimeras to distinguish the MHC class I alleles expressed on bone marrow-derived cells from those expressed on all other mouse cells and tissues. When analyzed, the data showed that antigen-specific CD8 T cell responses were restricted to the MHC class I alleles derived from the donor bone marrow. These findings indicate that a key step in DNA vaccination is:

Question

Quizplus · Accepted Answer

The key step in DNA vaccination is the presentation of peptides derived from the antigenic protein on MHC class I molecules of skin-resident dendritic cells. This is what leads to the activation of antigen-specific CD8 T cell responses. The other options are steps that may occur during DNA vaccination, but they are not the key step.

One Early Study on DNA Vaccines Examined the CD8 T