Neutrophils regulate the production of active cathelicidins (a class of antimicrobial peptides) by segregating the inactive propeptide from the processing enzyme that cleaves and activates it in two different types of cytoplasmic granules. These two types of granules are induced to fuse with phagosomes after ingestion of microbes, bringing the processing enzyme and the propeptide together.

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Neutrophils do regulate the production of active cathelicidins by segregating the inactive propeptide from the processing enzyme in two different granules, which fuse with phagosomes after ingestion of microbes to activate the antimicrobial peptides.

Neutrophils Regulate the Production of Active Cathelicidins (A Class of Antimicrobial