Question 1

Use the following to answer questions 
Choose the correct answer from the list below. Not all of the answers will be used.
-A purine or pyrimidine base linked to a sugar is a(n) _________________.

Accepted Answer

A nucleoside is a purine or pyrimidine base linked to a sugar.

Question 2

Use the following to answer questions 
Choose the correct answer from the list below. Not all of the answers will be used.
-The final product of purine degradation is _________________.

Accepted Answer

The final product of purine degradation is urate, which is a precursor to the development of gout.

Question 3

The committed step in purine nucleotide biosynthesis is the conversion of __________________ to 5-phosphoribosyl-1-amine.

Accepted Answer

PRPP

Question 4

Use the following to answer questions 
Choose the correct answer from the list below. Not all of the answers will be used.
-Assembly of a compound from phophoribosylpyrophosphate (PRPP) and a base is known as a(n) _________________ pathway.

Accepted Answer

The answer of Use the following to answer questions 
Choose...

Question 5

Use the following to answer questions 
Choose the correct answer from the list below. Not all of the answers will be used.
-The intermediate between inosinate and guanylate is _________________.

Accepted Answer

Xanthylate is the intermediate between inosinate (IMP) and guanylate (GMP) in the purine nucleotide biosynthesis pathway.

Question 6

Hypoxanthine-guanine phosphoribosyltransferase catalyzes the formation of guanylate and __________________.

Accepted Answer

The answer of Hypoxanthine-guanine phosphoribosyltransferase catalyzes the formation of guanylate...

Question 7

Use the following to answer questions 
Choose the correct answer from the list below. Not all of the answers will be used.
-A purine or pyrimidine base linked to a sugar and to a phosphate ester is a(n) _________________.

Accepted Answer

A base linked to a sugar and a phosphate ester is a nucleotide.

Answer: I
 A nucleoside is a base linked to a sugar, but not to a phosphate ester.

Answer: L
 Salvage refers to the process of using free bases to create nucleotides, rather than creating bases de novo (choice A).

Question 8

Use the following to answer questions 
Choose the correct answer from the list below. Not all of the answers will be used.
-High levels of urate cause the disease _________________.

Accepted Answer

High levels of urate cause gout.

Question 9

Fluorouracil acts as an analog of __________________.

Accepted Answer

The answer of Fluorouracil acts as an analog of __________________....

Question 10

In __________________ biosynthesis, the base is assembled first and then attached to ribose.

Accepted Answer

The answer of In __________________ biosynthesis, the base is assembled...

Question 11

Use the following to answer questions 
Choose the correct answer from the list below. Not all of the answers will be used.
-Assembly of a compound from simpler molecules is known as a(n) _______________ pathway.

Accepted Answer

Assembly of a compound from simpler molecules is known as a de novo pathway, which refers to the synthesis of complex molecules from simple molecules.

Question 12

The conversion of ribonucleotides to deoxyribonucleotides is catalyzed by ________________.

Accepted Answer

The answer of The conversion of ribonucleotides to deoxyribonucleotides is...

Question 13

__________________ disease is caused by a genetic mutation resulting in the absence of hypoxanthine-guanine phosphoribosyltransferase.

Accepted Answer

The answer of __________________ disease is caused by a genetic...

Question 14

DNA is built from __________________.

Accepted Answer

The answer of DNA is built from __________________....

Question 15

Use the following to answer questions 
Choose the correct answer from the list below. Not all of the answers will be used.
-The methyl donor to make TMP is _________________.

Accepted Answer

N5, N10-methylenetetrahydrofolate is the methyl donor used to make TMP.

Question 16

Scaffolds for the ring systems in nucleotides are from the amino acids glycine and __________________.

Accepted Answer

The answer of Scaffolds for the ring systems in nucleotides...

Question 17

Dihydrofolate reductase is an excellent target for anticancer drugs because it is critical in the synthesis of __________________.

Accepted Answer

The answer of Dihydrofolate reductase is an excellent target for...

Question 18

Some individuals with a deficiency in the enzyme adenosine deaminase exhibit __________________.

Accepted Answer

The answer of Some individuals with a deficiency in the...

Question 19

Use the following to answer questions 
Choose the correct answer from the list below. Not all of the answers will be used.
-Purines and pyrimidines are derived from _________________.

Accepted Answer

The answer of Use the following to answer questions 
Choose...

Question 20

Use the following to answer questions 
Choose the correct answer from the list below. Not all of the answers will be used.
-CTP is formed by the amination of _________________.

Accepted Answer

CTP is formed by the amination of UTP (uridine triphosphate).

Quiz 32: Nucleotide Metabolism

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -A purine or pyrimidine base linked to a sugar is a(n) _________________.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -The final product of purine degradation is _________________.

The committed step in purine nucleotide biosynthesis is the conversion of __________________ to 5-phosphoribosyl-1-amine.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -Assembly of a compound from phophoribosylpyrophosphate (PRPP) and a base is known as a(n) _________________ pathway.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -The intermediate between inosinate and guanylate is _________________.

Hypoxanthine-guanine phosphoribosyltransferase catalyzes the formation of guanylate and __________________.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -A purine or pyrimidine base linked to a sugar and to a phosphate ester is a(n) _________________.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -High levels of urate cause the disease _________________.

Fluorouracil acts as an analog of __________________.

In __________________ biosynthesis, the base is assembled first and then attached to ribose.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -Assembly of a compound from simpler molecules is known as a(n) _______________ pathway.

The conversion of ribonucleotides to deoxyribonucleotides is catalyzed by ________________.

__________________ disease is caused by a genetic mutation resulting in the absence of hypoxanthine-guanine phosphoribosyltransferase.

DNA is built from __________________.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -The methyl donor to make TMP is _________________.

Scaffolds for the ring systems in nucleotides are from the amino acids glycine and __________________.

Dihydrofolate reductase is an excellent target for anticancer drugs because it is critical in the synthesis of __________________.

Some individuals with a deficiency in the enzyme adenosine deaminase exhibit __________________.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -Purines and pyrimidines are derived from _________________.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -CTP is formed by the amination of _________________.