The "one gene-one enzyme" hypothesis states that

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The "one gene-one enzyme" hypothesis was proposed by George Beadle and Edward Tatum based on their experiments with Neurospora, a type of bread mold. They found that mutations in specific genes resulted in deficiencies in the production of specific enzymes, suggesting that each gene was responsible for the production of a specific enzyme. However, the hypothesis was later modified to the "one gene-one polypeptide" hypothesis, which recognizes that not all genes encode enzymes and that some genes may encode multiple polypeptides through alternative splicing or post-translational modifications. Nevertheless, the central idea behind the hypothesis is that the function of an individual gene is to dictate the production of a specific polypeptide.

The "One Gene-One Enzyme" Hypothesis States That