Testosterone and estradiol are male and female sex hormones, respectively, in many vertebrates. In what way(s) do these molecules differ from each other?

Question

Quizplus · Accepted Answer

Testosterone and estradiol have the same carbon skeleton, but they differ in the functional groups attached to it. Testosterone has a methyl group at the C-10 position and a keto group at the C-3 position, while estradiol has two hydroxyl groups at the C-3 and C-17 positions. This difference in functional groups leads to different biological activities and physiological effects in males and females.

Testosterone and Estradiol Are Male and Female Sex Hormones, Respectively