Which factor in a patient's medical history is most likely to prolong the half-life of certain drugs?

Question

Quizplus · Accepted Answer

Liver disease can impair the ability of the liver to metabolize drugs, which can lead to a prolonged half-life of certain drugs. The liver is responsible for breaking down drugs and eliminating them from the body, so if it is not functioning properly, drugs may stay in the body longer and accumulate to toxic levels. Heart disease, rheumatoid arthritis, and tobacco use may affect drug metabolism and clearance in different ways but they are not typically associated with a prolonged half-life of drugs.

Which Factor in a Patient's Medical History Is Most Likely