The MOST important contribution to the stability of a protein's conformation appears to be the:
A) entropy increase from the decrease in ordered water molecules forming a solvent shell around it.
B) maximum entropy increase from ionic interactions between the ionized amino acids in a protein.
C) sum of free energies of formation of many weak interactions among the hundreds of amino acids in a protein.
D) sum of free energies of formation of many weak interactions between its polar amino acids and surrounding water.
E) stabilizing effect of hydrogen bonding between the carbonyl group of one peptide bond and the amino group of another.

Question

Quizplus · Accepted Answer

CDThe stability of a protein's conformation is significantly influenced by the entropy increase from the decrease in ordered water molecules forming a solvent shell around it (A), the sum of free energies of formation of many weak interactions among the hundreds of amino acids in the protein (C), and the sum of free energies of formation of many weak interactions between its polar amino acids and surrounding water (D). These factors contribute to the hydrophobic effect, the overall stability through weak interactions, and the interaction with the solvent, respectively, all of which are crucial for protein folding and stability.

The MOST Important Contribution to the Stability of a Protein's