Name one amino acid whose oxidation proceeds via the intermediate shown:

Question

Quizplus · Accepted Answer

The question asks to name one amino acid whose oxidation results in the formation of each of the listed intermediates in the metabolic pathway. Here are the amino acids that correspond to each intermediate:
(a) Pyruvate: Alanine is an amino acid that can be directly converted into pyruvate through a transamination reaction. The enzyme alanine aminotransferase (ALT) catalyzes this reaction, where the amino group from alanine is transferred to $\alpha$-ketoglutarate to form pyruvate and glutamate.
(b) Oxaloacetate: Aspartate is an amino acid that can be converted into oxaloacetate. The enzyme aspartate aminotransferase (AST) catalyzes the transamination of aspartate and $\alpha$-ketoglutarate to oxaloacetate and glutamate.
(c) $\alpha$-Ketoglutarate: Glutamate is an amino acid that can be directly converted into $\alpha$-ketoglutarate by the enzyme glutamate dehydrogenase through oxidative deamination.
(d) Succinyl-CoA: Isoleucine, methionine, threonine, and valine are amino acids that can be catabolized to succinyl-CoA. For example, the catabolism of methionine involves several steps, including the conversion of homocysteine to cystathionine, then to $\alpha$-ketobutyrate, and eventually to succinyl-CoA.
(e) Fumarate: Phenylalanine and tyrosine are aromatic amino acids that can be catabolized into fumarate. The catabolic pathway involves several steps, including the conversion of phenylalanine to tyrosine (via phenylalanine hydroxylase), and then through a series of reactions, tyrosine is broken down into fumarate and acetoacetate.
Please note that the intermediate listed as "$\alpha$-ketoglutarate" seems to be a typographical error or a misprint. The correct intermediate is likely meant to be $\alpha$-ketoglutarate, as mentioned above.

Name One Amino Acid Whose Oxidation Proceeds Via the Intermediate α\alphaα

Name One Amino Acid Whose Oxidation Proceeds Via the Intermediate $\alpha$