It is not possible to have an interaction effect in a two-way ANOVA unless one of the factors has a main effect.

Name: It is not possible to have an interaction effect in a two-way ANOVA unless one of the factors has a main effect.
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Quizplus · Accepted Answer

It is possible to have an interaction effect even if neither factor has a main effect. An interaction occurs when the effect of one factor depends on the levels of another factor, regardless of whether there are significant main effects present.

It Is Not Possible to Have an Interaction Effect in a Two-Way