One of the roles of the kidneys is to help buffer body fluids, to keep fluids from becoming too acidic or too basic. The cells of the renal tubule wall secrete H+ into the tubule lumen, and absorb bicarbonate, passing it into the tissue fluid. Consider the reaction catalyzed by the enzyme carbonic anhydrase, shown in the accompanying figure and below.
During heavy exercise, the reaction shifts to the right in the interstitial fluid around the nephron.
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