Genetics: Analysis and Principles 5th Edition by Robert Brooker

تمرين 43

Like Hurler syndrome, Fabry disease involves an abnormal accumulation of substances within lysosomes. However, the lysosomes of individuals with Fabry disease show an abnormal accumulation of lipids. The defective enzyme is -galactosidase A, which is a lysosomal enzyme that functions in lipid metabolism. This defect causes cell damage, especially to the kidneys, heart, and eyes. The gene that encodes -galactosidase A is found on the X chromosome. Let's suppose a phenotypically unaffected couple produces two sons with Fabry disease and one phenotypically unaffected daughter. What is the probability that the daughter will have an affected son