Biochemistry 4th Edition by Reginald Garrett, Charles Grisham

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The number of clones needed to screen a very large genomic library at 99% confidence
The South American lungfish has a genome size of 10.2 x 10 10 bp. If a genomic library of lungfish DNA was constructed in a cosmid vector capable of carrying inserts averaging 45 kbp in size, how many individual clones would have to be screened to have a 99% probability of finding a particular DNA fragment