Biochemistry 4th Edition by Reginald Garrett, Charles Grisham

تمرين 11

Protein kinase specificity via consensus target sequences and intrasteric control
Consult Table 15.2 and
a. Suggest a consensus amino acid sequence within phosphorylase kinase that makes it a target of protein kinase A (the cAMP-dependent protein kinase).
b. Suggest an effective amino acid sequence for a regulatory domain pseudosubstrate sequence that would exert intrasteric control on phosphorylase kinase by blocking its active site.