Biochemistry 4th Edition by Reginald Garrett, Charles Grisham

تمرين 13

Energetics of PEP Hydrolysis (Integrates with Chapter 3.) The standard free energy change ( G °') for hydrolysis of phosphoenolpyruvate(PEP) is -62.2 kJ/mol. The standard free energy change( G °') for ATP hydrolysis is -30.5 kJ/mol.
a. What is the standard free energy change for the pyruvate kinase reaction:

b. What is the equilibrium constant for this reaction
c. Assuming the intracellular concentrations of [ATP] and [ADP]remain fixed at 8 m M and 1 m M , respectively, what will be the ratio of [pyruvate] / [phosphoenolpyruvate] when the pyruvate kinase reaction reaches equilibrium