Biochemistry 4th Edition by Reginald Garrett, Charles Grisham

تمرين 10

Understanding the energetics of the aconitase reaction
(Integrates with Chapter 3.) Aconitase catalyzes the citric acid cycle reaction:
citrate isocitrate
The standard free energy change, G°', for this reaction is +6.7 kJ/mol. However, the observed free energy change ( G) for this reaction in pig heart mitochondria is +0.8 kJ/mol. What is the ratio of [isocitrate]/[citrate] in these mitochondria If [isocitrate] = 0.03 mM, what is [citrate]